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See Box 33-3for a summary of the interview technique.

These phase III clinical trials (as discussed in Chapter 5) involve large numbersof subjects and are often set within a more general (and typically sponsored) researchprogram.

Although it has long beenrecognized that AD pathology is the most commonpathology underlying dementia, we now know thatolder persons with dementia most often have mixedbrain pathologies, most commonly AD pathology andinfarcts, followed by AD and LBs (MRC CFAS, 2001;White et al., 2005; Schneider et al., 2007a; Sonnen etal., 2007; O’Brien et al., 2009; Nelson and Abner, 2010).Furthermore, it is recognized that older persons with-out cognitive impairment may have many of the sametypes and burdens of pathologies as in persons withdementia, suggesting neural or cognitive reserve andsubclinical disease (Elkins et al., 2006; Rentz et al., 2010;Tucker and Stern, 2011). They also feel powerless torepair the loss that their loved ones will suffer or that others have faced as aresult of a dying person’s past actions

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